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Kijima T, Fukushima H, and Kusuhara S, et al (2020) Association between the occurrence and spectrum of immune-related adverse events and efficacy of pembrolizumab in asian patients with advanced urothelial cancer: multicenter retrospective analyses and systematic literature review Clin Genitourin Cancer 19 208216 PMID: 32800718 63

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The American Thyroid Association guideline on levothyroxine dosing already recommends separating levothyroxine from other drugs and food by 30 to 60 minutes [8]

However, a notable side effect was observed: MT-II-treated normal C57BL/6J mice exhibited significant weight loss, with their average weight decreasing from a baseline of 30.9 1.4 grams to 26.5 1.7 grams after the 14-day treatment course, a change not seen in vehicle-treated controls