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95% CI, -6.7 to -4.3

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Methionine biosynthesis occurs in three consecutive reactions catalyzed by cystathionine -synthase (CGS), cystathionine -lyase (CBL), and methionine synthases (MS) (Ravanel et al., 1998b)

The dosage of saxagliptin is 2.5 mg once daily when co-administered with a strong cytochrome P450 3A4/5 inhibitor (e.g., ketoconazole, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin) (package insert)