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Similarly, 3-HAA exerts cytoprotective effects by upregulating the antioxidant enzyme heme oxygenase-1 and inhibiting NO synthase activity [120, 123, 165], suggesting that KP metabolites may initially serve adaptive functions during acute stress

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We prescribe Disease-Modifying Anti-Rheumatic Drugs (DMARDs) and biologics to help control inflammation, protect joint tissues, and prevent long-term damage

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The CNS influences motor, sensory, autonomic and secretory aspects of the gastrointestinal tract, integrates interoceptive information from the gut and returns responses, thus mediating the actions and reactions necessary to support gut and brain health 98

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Monitor skin changes regularly

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