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Sivelestat significantly reduces ferroptosis severity and improves survival rates of a mouse S-ALI model by inhibiting NET formation, protecting pulmonary vascular endothelial glycocalyx (SDC-1/HS) integrity, and activating the HGF/cMET pathway ( 4 Targeting ferroptosis with natural products for the treatment of S-ALI and SLI Here, we summarize the regulatory effects of natural products on ferroptosis in S-ALI and SLI (Tables 2, 3)

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Second, decreased expression or serine phosphorylation of IRS proteins 44,45 can reduce their binding to PI3K, thereby down-regulating PI3K activation and inducing apparent IR

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