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10.2174/1381612826666200424180139 [DOI] [PubMed] [Google Scholar] Sikiric P., Hahm K

Gastrointestinal issues, such as nausea, vomiting, diarrhea, and constipation, are common during the initial stages of treatment

While these gastrointestinal effects are dose-dependent and typically occur during initial treatment or dose escalation, most patients find symptoms diminish over time