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Below GLP-1s, below approved oral pharmacotherapy, below surgery for appropriate candidates and beside, not instead of, diet and exercise
By inhibiting NNMT and preserving NAD, 5-Amino-1MQ indirectly boosts SIRT1 activity , leading to: Increased fat oxidation SIRT1 activates PGC-1 (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), a master regulator of mitochondrial biogenesis and fat metabolism
(PubMed) Ho C, Kauwell GP, Bailey LB
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