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Collilineatus venom containing crotapotin protects PC12 cells against MPP (+) toxicity by activating the NGF-signaling pathway

Determination of ssDNA breaks, 23 mitochondrial membrane depolarization, 24 caspase cleavage 24 and apoptotic DNA fragmentation 23 was carried out as previously described

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DOI: 10.1016/S0140-6736(21)00845-X Frias JP, Deenadayalan S, Erichsen L, Knop FK, Lingvay I, Macura S, et al

Crudely, all of this means that DHEA-S helps keep that fire going that the excitatory neurons are firing properly, but also that the fire is burning "just right" and is not out of control