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Underpinning this crosstalk is metabolic reprogrammingsuch as enhanced glycolysis in macrophages and increased polyunsaturated fatty acid (PUFA) synthesis in epithelial cellswhich supplies the substrates necessary for both ferroptosis and immune activation, closing a vicious cycle

Months 3 to 6: Complete the minimum lifestyle-intervention period required by your region's step-therapy protocol

Yes, but it requires careful monitoring for low blood sugar and your insulin dose may need to be adjusted by your doctor. What lifestyle factors maximize benefit and minimize risk

Which is what youve put together

These objective markers confirm whether the protocol is producing metabolic benefits beyond weight loss