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The resulting cystathionine is converted into cysteine, a precursor of glutathione, and -ketobutyrate by -cystathionase, which is also dependent on pyridoxal-5-phosphate (Fig

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The duration of the trials varied: one lasted 26 weeks [25], four spanned 40 weeks [31,32,35,37], five extended to 52 weeks [29,30,33,34,36], and three covered 72 weeks [26-28]

Ferritin, B12, vitamin D, thyroid function, and a comprehensive metabolic panel will cover the most common correctable causes