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Other research has also identified that abundance of Firmicutes plays a role in altering BBB function and found that the ratio of Firmicutes/Bacteroidetes increased in aging mice as well as the alpha diversity (the mean species diversity), while the BBB function became impaired [96]

J Clin Endocrinol Metab 92:229234 Perez-Tilve D, Heppner K, Kirchner H, Lockie SH, Woods SC, Smiley DL, Tschop M, Pfluger P (2011) Ghrelin-induced adiposity is independent of orexigenic effects

Fractures, thickened joint tissue, or severe joint damage may require surgery

Quick answer: Carnitine safety is not only about stomach upset

As a result, clinicians must consider how gastrointestinal tolerability evolves once patients move beyond the controlled environment of trials