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In the gastrointestinal tract, COX-1-derived prostaglandins function to increase production of the thick mucus/bicarbonate layer that coats gastric surfaces and buffers them against stomach acid (Vonkeman 2010)

Small changes in the time of administration relative to ischemia can shift PRPs effect from anti-apoptotic to apparently pro-inflammatory, as shown in models where PRP given before ischemia produced stronger protective outcomes than when applied at reperfusion 52

Autoimmune and Chronic Inflammatory Conditions Oxidative stress is believed to underlie the pathology of a range of autoimmune and chronic inflammatory conditions

10.3389/fphar.2021.794997 Front Pharmacol

However, to date, no structural data is available in order to elucidate the orientation of HQ in the active site of tyrosinase