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Together, these results show that the decrease of DUB activity temporally precedes proteasome inhibition in the aging mouse brain, and that chronic impairment of DUBs in neurons leads to partial inhibition of proteasome activity

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Peer review Peer review information Nature Chemical Biology thanks G

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They also interact with appetite hormones, making you less hungry but potentially more prone to nausea if you eat too quickly, too much, or the wrong foods

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