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The molecular mechanisms of the HBD of IGFBP-2 needs to be determined, but the HBD is implicated in downregulating PTEN expression and activates IGF-I signaling pathway in osteoblasts, indicating that the effect of the HBD on bone acquisition is in part mediated by the reduction of PTEN expression in osteoblastic cells

That said, these molecules also have useful roles, such as fighting off infection

C., Kennouche, P., Reniere, M

This is important for autoimmune diseases, because one of the root causes of autoimmune diseases is toxicity from heavy metals, mold, chemicals and potentially medications

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