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The trial was designed to assess the efficacy and safety of semaglutide, a once-weekly subcutaneous glucagon-like peptide 1 (GLP-1) receptor agonist, in preventing major kidney outcomes, specifically kidney failure, substantial loss of kidney function, and death from kidney or cardiovascular causes, in individuals with type 2 diabetes and chronic kidney disease

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Allergic reactions Hives, rash, facial or throat swelling, or trouble breathing, require immediate medical attention Thyroid tumors Animal studies on liraglutide showed a risk of thyroid C-cell tumors, so generic liraglutide carries the same boxed warning as Saxenda

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Nutritional supplementation with l-carnitine could mitigate these pathophysiological processes by inhibiting NF-B and down-regulating NOX1/NOX2, thereby enhancing the antioxidant effects of angiotensin II 636