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29 Los iSGLT2 eliminan 60-80 gramos de glucosa al da por orina y este efecto es independiente de la funcin de la clula beta y del tiempo de evolucin de la diabetes mellitus tipo 2, por lo que pueden prescribirse en cualquier momento de la enfermedad (Figura 2)

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173, 174 Contrary to mice that appear fit and viable even with very high tumor masses, humans generally develop advanced cachexia and die when tumor masses have already reached 0.1% of body weight

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