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Mar 2016;95(10):e2895

Tirzepatide is FDA-approved for Type 2 diabetes and being studied extensively for weight loss

Functionally, cagrilintide activates amylin receptors AMY1R, AMY2R, AMY3R and the calcitonin receptor (CTR), binding via a conserved bypass motif involving mid-segment residues (S19 P25) (Cao et al