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Participants were randomized 1:1:1 to retatrutide 9 mg weekly, retatrutide 12 mg weekly, or placebo, with treatment lasting 68 weeks

Starting at the lowest dose and titrating slowly significantly reduces GI side effects

93, 94 Recent clinical data also indicates that variants of GTP cyclohydrolase I are governing NO production, autonomic activity and even cardiovascular risk

Tirzepatide: A newer dual-action medication that targets both GLP-1 and GIP receptors

In recent years, GLP-1 medications like Ozempic have progressed from a specialised diabetes treatment into a more widespread weight loss tool used by a wide range of people globally