However, a Mediterranean-style or whole-food-based approach is often recommended: plenty of vegetables, healthy fats (like olive oil), lean proteins, and minimal added sugars
The results in aged mice were particularly striking

The 6-variable model includes patient age (U-shaped relationship), diabetes type (nearly doubled risk with type 1 diabetes), HbA 1c (U-shaped relationship), creatinine clearance (small increase in risk with worse renal function), severe hypoglycemia within the prior year (4-fold higher risk), and insulin use (2.3-fold higher risk).[108] While clinical practice guidelines recommend raising glycemic targets for patients at high risk for hypoglycemia,[17] this strategy alone may not be sufficient.[109, 110] A more effective approach may be to proactively de-intensify treatment regimens of overtreated patients.[111, 112] Potential overtreatment of adults with type 2 diabetes is common, including among older adults, patients with advanced kidney disease and dementia, and patients with high clinical complexity.[83, 113115] These patients are at highest risk for hypoglycemia, yet because of their multi-morbidity and limited life expectancy they also derive less benefit from intensive glycemic control

With aspirin or loop diuretics, changes often fade once the drug stops
Inadequate carbohydrate intake (usually ketotic) Starvation, anorexia nervosa