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Low methionine levels can affect the production of A-adenosylmethionine (SAMe), a major methyl donor for the central nervous system and an essential nutrient required for the production of neurotransmitters

Side effects from B12 injections are rare, but some individuals may experience mild soreness or redness at the injection site

VITAstir is my go to for B12 which I need for my Pernicious Anemia treatment

doi:10.1152/ajplegacy.1969.216.2.436 [6] Rayman MP

Side effects and cautions B12 has no established upper limit due to low toxicity, but injections can have side effects: Common: soreness, redness or swelling at the injection site