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10.1111/ene.13272 Eur

Around the period of Earth's transition from anaerobic to aerobic conditions about 2.4 billion years ago (bya), the evolution of SOD enzymes crucially allowed organisms to overcome the effects of oxidative stress following the surge of molecular oxygen (O 2 ) in the atmosphere (Miller 2012)

Psychiatry 59 , 11161127 (2006)

Supplementing with a conventional glutathione supplement that goes through the digestive system will eventually end up as a free amino in the blood due to hydrolysis of glutathione by intestinal and hepatic gamma-glutamyltransferase

The specific expression of these enzymes involved in the local production of cytotoxic/bioactive drugs has been exploited to design and develop various types of anticancer prodrugs