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This is the process known to be responsible for significant damage to - and premature aging of - our cells

Figure 1 In line with these observations, weight loss has emerged not only as a supportive strategy but also as a disease-modifying intervention in PsA ( Preclinical studies further suggest that GLP-1RAs may modulate key cytokine pathways implicated in psoriatic disease, including NF-B, IL-6, IL17, and IL23, while small clinical studies have reported improvements in skin disease severity in PsO ( This narrative review summarizes the current clinical evidence on GLP-1RAs in PsO and PsA and discusses future research directions aimed at evaluating their potential role in intercepting PsA development and improving outcomes in patients with complex immunometabolic profiles

Mindful eating: Practice mindful eating techniques, such as eating slowly, savoring each bite, and paying attention to hunger and fullness cues

Rest and very mild exerciseno more than 10 minutes of walkingare usually all the patient can manage

It is an important part, as we will see, but reducing fertility to weight alone is dangerously simplistic