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A recent randomized controlled trial indicated that vitamin B12 supplementation significantly decreased serum levels of homocysteine compared to placebo, while no significant difference was revealed in between-group comparisons for fasting blood glucose, malondialdehyde, and liver steatosis (55)

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Simonsen E., Lund LC, Thomsen Ernst M., Hjellvik V., Hegeds L., Hamann S., Kalsnes Jrstad ., Lvdal Gulseth H., Karlstad ., Pottegrd A., 2024 Dec 11 Use of semaglutide and risk of non-arteritic anterior ischemic optic neuropathy: A DanishNorwegian cohort study medRxiv preprint doi: 10.1101/2024.12.09.24318574 Agenda PRAC statistics: January 2025 Glossary Safety signal assessments