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- If taking medications indicated for control of AD symptoms, on stable doses for at least 8 weeks prior to screening Exclusion criteria - Any history of bipolar affective disorder - A medical condition, other than AD, that may contribute to the individuals cognitive impairment - Stroke or transient ischemic attack in the past 12 months - Clinically significant unstable psychiatric condition in the past 6 months - Inability to swallow oral medications - Other medical conditions which the investigator deems would limit the individuals life expectancy to less than 6 months - Concurrent use of anti-depressant medication - Participation in another interventional clinical trial, or intake of another investigations drug within 4 weeks or 5 half-lives (whichever is longer) Study Estimands Primary estimand 1

Starting an exercise regimen also increased glutathione in sedentary young adults

These effects typically resolve as the body adapts, and they are generally manageable compared to the benefits of improved glucose control and sustained weight loss

Predisposing factors to CMD like DM, obesity, hypertension, dyslipidaemia, and ageing result in vascular dysfunction partly through oxidative stress [64]