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Low total GSH and high homocysteine levels are considered as novel risk markers for acute stroke severity, and low total and reduced GSH levels may be potential risk markers for stroke severity and insufficient functional independence in large-artery atherosclerosis (157, 158)

doi: 10.3389/fnmol.2022.947513 Received 18 May 2022 Accepted 18 July 2022 Published 15 August 2022 Volume 15 - 2022 Edited by Salam Salloum-Asfar, Qatar Biomedical Research Institute, Qatar Reviewed by Sara A

If your liver is sluggish, you might end up with "estrogen dominance," a state where estrogen levels are too high relative to progesterone

10.1038/nrneurol.2012.58 31 BirgerA.Ben-DorI.OttolenghiM.TuretskyT.GilY.SweetatS.et al

but not only ions are responsible for this early BBB disruption, other mediators such as aquaporins, matrix metalloproteases (MMP), inflammatory cells, bradykinin, vascular endothelial growth factor, and nitric oxide synthase appear to have a role (76, 77)