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Deficiencies in all of the genes responsible for overall metabolism of cobalamin are associated with various forms of methylmalonic acidemia

This makes retatrutide different from some approved medicines

Therefore, more efforts should be taken to develop metal-based nanoplatforms with excellent targeting specificity to cancer cells based on the characteristics of TME and GSH exhaustion mechanisms

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While the gut-skin axis is an emerging area of research, direct connections between tirzepatide-induced GI effects and skin changes remain speculative and not established in clinical studies