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Most children with GDH-HI have hyperammonemia, with blood ammonia levels are 25 times above the upper limit of normal

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As potent compounds like semaglutide and tirzepatide move beyond tightly controlled clinical settings, the need for disciplined documentation and supply-chain visibility increases

Consistent with all these in vitro and in vivo findings, the liver could be identified as the major organ involved in the rapid erythrocyte removal and iron recycling