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Both Ozempic and Wegovy are given once a week, while Rybelsus is taken daily

Side-by-side comparison Factor Receptor targets Semaglutide GLP-1 only Tirzepatide GLP-1 + GIP Retatrutide GLP-1 + GIP + glucagon Liraglutide GLP-1 only Factor Half-life Semaglutide ~7 days Tirzepatide ~5 days Retatrutide ~6 days Liraglutide ~13 hours Factor Dosing frequency Semaglutide Once weekly Tirzepatide Once weekly Retatrutide Once weekly Liraglutide Once daily Factor Max studied dose Semaglutide 2.4 mg/week (SubQ)

Usage was more commonly reported among girls

Colitisinflammation of the colonhas not been identified as a recognized adverse effect in the pivotal SUSTAIN trials for diabetes management or the STEP trials for weight management

i.e., weight maintenance and weight loss, in concomitance with a controlled intake of calories and improved physical activity, studies of three 68 weeks double-blind, placebo-controlled, randomized trials were conducted