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Glutathione S -transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1

Clinical studies using ultramicronized PEA-LUT have administered 100600 mg/day luteolin equivalents for 212 weeks without any serious adverse events ( Several pharmacokinetic considerations warrant attention

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Rutgers 2011)

A higher risk of deficiency is present in patients with malabsorptive syndrome and/or unusually low sun exposure, those who have undergone gastric bypass surgery, or those on prolonged glucocorticoid use (which alters intestinal absorption) (46)