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The main sources of iron in the body are the recycling of damaged erythrocytes and dietary iron [18]

It remains at rest for 1h in a thermostated enclosure that maintains the rectal temperature of the animal at 38 o C throughout the manipulation

Non-genetic predictors of BMI loss To analyse the dependence of achieved BMI loss on non-genetic factors such as drug type, dosage and time on treatment, we fit the following model: where drugType is an indicator variable that equals 1 for individuals using semaglutide and 0 for tirzepatide, dose represents the dose in milligrams, days treat represents the total days on the relevant drug and : represents an interaction term between two or more variables

To further evaluate robustness, we additionally performed a random-effects meta-analysis, which yielded results highly consistent with the fixed-effect inverse-varianceweighted approach

Mol Aspects Med 34(23):108120