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At this time, there is insufficient human data to determine whether BPC-157 affects fertility, reproductive health, pregnancy outcomes, or breastfeeding safety

Also, TGR5 seems to have an important role in the maintenance of intestinal barrier integrity, since murine models TGR5 deficient developed an increased intestinal permeability, made of an altered molecular architecture of epithelial thigh junctions with an increased expression and an abnormal distribution of zonulin-1 [25]

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