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The accumulation of misfolded proteins, will exert mitochondrial stress (DellAnna et al., 2001), in which nucleus receives a signal and ultimately activates UPR (Harris, 2016), that help reestablish the ER homeostasis by increasing the protein folding capacity of the ER, and decrease the ER protein folding loads

Glutathione supplementation tends to make the most sense for a few specific groups, rather than being a universal need for every adult

Which raises an important question: If youre optimizing hormones but ignoring cellular defense, are you really optimizing health

Why IV/IM over oral: oral glutathione has low bioavailability (much is broken down in digestion)

Oral iron is effective for mild deficiency