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Published clinical research has characterised the compound in controlled trials: a Phase 2 obesity trial reported dose-dependent body-weight change in the study population (Jastreboff et al., 2023), and a separate Phase 2 trial investigated the GIP/GLP-1/glucagon agonist in people with type 2 diabetes (Rosenstock et al., 2023)

**Skipping the room-temperature step:** Cold powder dissolves poorly and may leave undissolved particles that look like contamination

The widespread distribution of GLP-1 receptors means that activating them produces ripple effects across multiple organ systems, and each new study reveals additional potential applications

Overall, 30%-41% of patients achieved 5% weight loss

(10(8)) doi:10.3390/children10081341