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Dose-Dependent Effects of Recombinant Human Insulin-like Growth Factor (IGF)-I/IGF Binding Protein-3 Complex on Overnight Growth Hormone Secretion and Insulin Sensitivity in Type 1 Diabetes

10.1016/0165-0173(93)90009-o 36 ColleyP

However, robust quantitative translation between administered experimental doses and plausible human internal burdens remains highly uncertain due to variability in exposure assessment assumptions, limited size-resolved data on internal PET burdens in humans (particularly for the nanoscale fraction), and methodological constraints in detecting and characterising sub-micrometre particles in complex biological matrices

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Boosted metabolism Essential for metabolic processes, B12 injections may help regulate appetite and support healthy weight management