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2022, Exercise Adaptation. NCBI Bookshelf , National Library of Medicine, U.S

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FIGURE 3 On the other hand, at increased levels, UA is considered as a marker of oxidative stress (Strazzullo and Puig, 2007) due to accumulation of reactive oxygen species (Hayden and Tyagi, 2004)

That damage produces free radicals, which can create even more cell damage

Furthermore, it has been observed that, in HG-induced rat retinal endothelial cells and STZ-induced SD rat models, it was found that PKC /Drp1 mediated mitochondrial fission increased and HK-II-PINK1 mediated mitophagy decreased