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[256] identified labile copper sources in the developing retina, and demonstrated that they modulate spontaneous activity of neural circuits via the copper transporter Ctr1, referred to as a copper ion channel ( see also section The source-target-physiology scheme for therapeutic intervention )

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Key significance: One of the first mitochondrial-derived peptides identified opened the field of MDP research DSIP (Delta Sleep Inducing Peptide) DSIP is a 9-amino-acid neuropeptide originally isolated from rabbit brain tissue during induced sleep

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