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In a study of apoptotic responses to TNF in cancer lines, GPx1 was shown to decrease thioredoxin oxidation to maintain the inactive thioredoxin-ASK1 complex by reducing ROS, as measured by DCF fluorescence

This may be due to an individual hypersensitivity, a dose that is too high for the person's current toxic load, or an imbalance in the body's oxidative state known as reductive stress

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