coadministered cagrilintide and semaglutide in adults with overweight or obesity Summary of REDEFINE 1 REDEFINE 2 trials CagriSema, presented this week at #ADA2025 and published NEJM: REDEFINE 1: • 👥 3,417 participants with (without diabetes) treated Cagrilintide–semaglutide (CagriSema) as an add-on

the FDA label includes a warning based on class effects of GLP-1 receptor agonists Thyroid C-cell tumors : Observed in rodent studies but no confirmed cases in humans

PlexusDx compounded semaglutide injections are $189/mo month-to-month, or from $149/mo on the 6-month plan from licensed 503A pharmacies and provide equivalent medical efficacy to Wegovy without brand markup

69 Cooking meals in batches for easy leftovers

The interaction between vitamin C and peptides is relevant for skin health, as is the combination of peptides and retinol for those using retinoids

Acknowledgments Financial support from FCT/MCTES through national funds UID/MULTI/04378/2019 and Norte Portugal Regional Coordination and Development Commission (CCDR-N)/NORTE2020/Portugal 2020 (Norte-01-0145-FEDER-000024) and a PhD grant (SRRH/BD/139622/2018) attributed to D