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doi: 10.3389/fphar.2014.00181 Received 31 May 2014 Accepted 16 July 2014 Published 11 August 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Marc Diederich, Laboratoire de Biologie Molculaire et Cellulaire du Cancer, Hpital Kirchberg, Luxembourg