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Once absorbed, intracellular esterases cleave the acetyl group, releasing active GSH

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To normalize the data and remove the impact of changes in prescribing volumes for all drugs, we divided by the total number of prescriptions in Truveta Data each month

We synthesized a 40-base RNA oligonucleotide encompassing the cleavage site and found that it can be cleaved into the predicted fragments, which was completely inhibited by 48c (Fig