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Spectral analyses of resting EEGs from dementia patients generally exhibit increased power in lower frequency waves and a decline in higher frequencies [48]

This enhances cellular defense against oxidative damage and inflammation, 31 playing a crucial role in APAP-induced liver injury

Clinical trials found no associated increase in arrhythmias or adverse cardiovascular events

It seems however, (at least based on a limited number of studies) that degeneration, loss of function, dysregulated metabolism, impaired second messenger signalling and death of astrocytes are predominant pathophysiological manifestations

Such work will clarify whether enhanced metabolic and antiinflammatory actions translate into measurable clinical benefit