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Some reasons patients consider deprescription include: Negative side effects Cost and coverage challenges Difficulty adhering to treatment Reaching their health goals Hitting a weight-loss plateau Preference not to remain on medication long term Without a comprehensive lifestyle and nutrition plan, many patients who stop GLP-1s regain the weight they lost

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The phenomenon of enzyme induction ensures increased availability of the particular CYP isoform that is appropriate for the substrate in question

Emerging data also point to benefits in conditions such as obstructive sleep apnea (OSA) and chronic kidney disease, including tirzepatide for moderate-to-severe OSA in adults with obesity and semaglutide for reducing kidney and cardiovascular risk in adults with CKD and T2D

(2024), underscoring the rich potential of botanical science in this field