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Changes in HbA1c throughout the study were also not associated with reduced MACE.24 Additionally, the multiple pleiotropic effects of SEMA on metabolic, hepatic and renal function may indirectly contribute to cardiovascular protection.25 The HFpEF programme shows significant symptomatic improvement of heart failure symptoms with preserved ejection fraction (HFpEF) in obese patients treated with SEMA 2.4 mg26 (Fig

C., and Van der Heiden, M

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Olfactory Dysfunction as an Early Biomarker in Parkinsons Disease

Furthermore, glucose uptake from the gastrointestinal tract is impaired in patients with bilateral total subdiaphragmatic vagotomy and pyloroplasty [35], thus suggesting a role of vagal mediation in GLP-1s incretin effect