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On the one hand, the activation of endoplasmic reticulum stress pathway in cancer cells can inhibit ferroptosis and participate in the induction of drug resistance
Holzforschung 59, 205209
It helps transport fatty acids into the mitochondria, where they are converted into energy, and supports brain health and cellular function
Larger chains may struggle to cross epithelial membranes because their physicochemical properties do not favor passive diffusion, and most are not transported efficiently through active transport pathways
Among these metabolic alterations, the dependency on the non-essential amino acid Gln stands out as a hallmark of cancer metabolism, often referred to as glutamine addiction [144,164,165]
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