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Immunohistochemistry was useful in making a diagnosis although the positivity for the melanocytic marker PRAME was unusual and unreported before

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The pending EVOKE and EVOKE Plus trials of daily oral semaglutide participants aged 5585 years with mild cognitive impairment or mild dementia due to Alzheimers disease with confirmed amyloid abnormalities by PET scan or cerebrospinal fluid biomarkers The only difference in the 2 trials is with respect to entry criteria with EVOKE Plus that allows for small vessel pathology