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Small Phase II ocular-surface studies of a pharmaceutical-grade formulation reported tolerability without notable adverse events in the treated populations, [18] and dermal-wound trials in venous stasis and pressure ulcers proceeded through early phases

Mandrika and colleagues (Biochem Pharmacol, 2001, PMID 11239505) examined melanocortin peptides on NF-B DNA binding in RAW 264.7 macrophage-like cells and reported evidence for dual mechanisms of action, and Kannengiesser and colleagues (Inflamm Bowel Dis, 2008, PMID 18092346) reported effects in murine colitis models that were partly independent of MC1R

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In biochemical and cellular research, GHKCu influences signalling activity through both its peptide component and the biochemical functions of copper itself

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