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While both tirzepatide and semaglutide reduced appetite, tirzepatide's superior weight loss outcomes suggest that other mechanisms, including increased energy expenditure, also play a role

And while GLP-1 medications are frequently prescribed for patients with vascular disease and Type 2 diabetes, there is a significant number of people who do not have Type 1 or Type 2 diabetes but do have vascular disease and overweight or obesity for whom these medications are often not available due to access to care issues, insurance coverage or other factors