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In patients in whom the major therapeutic goal is the compelling need to minimize the therapeutic risk pf hypoglycaemia, DPP-4 inhibitors are recommended as second line therapy after metformin failure at the same level as second line treatment options with GLP-1 receptor agonists, SGLT-2 inhibitors, or TZDs

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Relative expression levels were quantified using ImageJ software (National Institutes of Health)

By being implicated in the pathophysiology of atherosclerosis and incorporated into ASCVD risk assessment models, lipoproteins are important prognostic indicators of cardiovascular health