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How Does Treatment Duration Differ

A summary of the main factors influencing GLP-1 secretion is shown in the image below (Huber et al, 2024)

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Additive effects on weight loss were similarly demonstrated in the Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus (SUSTAIN-9) and Dulaglutide as add-on therapy to SGLT2 inhibitors in patients with inadequately controlled type 2 diabetes (AWARD-10) trials [103,104]