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The confirmed harms were a small increase in liver enzymes, a roughly 1% incidence of muscle symptoms, and a modest rise in blood sugar in patients already near the diabetes threshold

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For instance, the synergistic action of BRSV and Histophilus somni downregulated tight junction proteins and stimulated the aberrant secretion of matrix metalloproteinases (notably MMP1 and MMP3), thereby accelerating structural degradation and inflammatory infiltration 101

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