Ocular risks: recent matched cohort studies have suggested a potential association between semaglutide prescriptions and an increased risk of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) (Hazard Ratio 4.28, with inter-study estimates ranging from 4 to 7)
Cagnotta C, Lettera N, Cardillo M, Pirozzi D, Catalan-Matamoros D, Capuano A, et al
AlsolamiAAAlmalkiAAAlhedyanSYAlghamdiAAlzahraniSMDauseWRet al
Key Points Individuals with GSTM1 -positive and GSTT1 -positive genotypes are at increased risk for renal cell carcinoma (RCC) when occupationally exposed to certain toxicants Individuals with the GSTM1 -null genotype are at increased risk for bladder cancer, which might be potentiated by smoking and occupational hazards Data on the influence of GSTT1 polymorphism on the risk for transitional cell carcinoma (TCC) are inconsistent In the process of kidney cancerization, expression of GSTA isoenzymes is downregulated, which contributes to decreased antioxidant capacity in RCC and might enhance RCC growth In the malignant phenotype of TCC of the urinary bladder, upregulation of GSTT1 and GSTP1 might provide a reduced cellular environment and inhibit apoptotic pathways, respectively
Supplement stacks can complicate interpretation of B-vitamin and methylation markers
